The typically welcomed 'cheat day' as a typical theme in many diets and the popular ketogenic diet is no exception. Researchers discovered that a 75-gram dose of glucose is comparable to a big bottle of soda or a plate of fries.
"The ketogenic or keto diet plan has become really typical for weight-loss or to manage illness like type 2 diabetes. It includes eating foods rich in fats, moderate in protein, but extremely low in carbs and it causes the body to go into a state called ketosis," said Jonathan Little, associate teacher in the School of Health and Exercise Sciences at UBCO and research study senior author of the study released in the journal, 'Nutrients'.
Little said the diet can be very reliable due to the fact that once the body is in ketosis and starved Alka Tone Keto for its favored fuel glucose, the body's chemistry modifications and it starts to aggressively burn its fat stores. This causes weight reduction and can reverse the symptoms of illness like Type 2 diabetes.
"We had an interest in discovering what occurs to the body's physiology when a dose of glucose is reintroduced. Considering that impaired glucose tolerance and spikes in blood sugar level levels are understood to be related to an increased threat in heart disease, it made good sense to take a look at what was occurring in the capillary after a sugar hit," said Cody Durrer, UBC Okanagan doctoral trainee and study the very first author.
For their test, the researchers hired 9 healthy young males and had them consume a 75-gram glucose beverage before and after a seven-day high fat, low carb diet. The diet included 70 per cent fat, 10 per cent carbohydrates, and 20 percent protein, similar to that of a modern ketogenic diet plan.
"We were originally looking for things like an inflammatory response or lowered tolerance to blood sugar. What we found instead were biomarkers in the blood suggesting that vessel walls were being harmed by the abrupt spike in glucose," said Durrer.
Little said the most likely offender for the damage is the body's own metabolic response to excess blood sugar, which triggers capillary cells to shed and potentially die.
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"Even though these were otherwise healthy young males when we looked at their blood vessel health after taking in the glucose drink, the results appeared like they might have originated from someone with bad cardiovascular health. It was rather alarming," added Little.
The scientists pointed out that with just 9 people included in the study, more work is needed to verify their findings, but that the outcomes need to give those on a keto diet plan pause when thinking about a cheat day.
"My issue is that a number of the individuals going on a keto diet-- whether it's to reduce weight, to deal with Type 2 diabetes, or some other health factor-- may be undoing a few of the positive impacts on their capillary if they unexpectedly blast them with glucose. Specifically if these people are at a higher risk for heart disease in the first place," he stated.